Hey, Cinemania. Here's what I know...and what I don't know.
The Hellboy II poster I have is single sided, non-glossy, and printed on very thick stock and -- it is numbered with what appears to be gold paint, not marker. To the touch, you can feel that it is slightly raised on the poster's surface, not an imprint. I did not buy it at the convention, but I did buy mine from a dealer I trust on Ebay at the time that it was released. It is not signed by Drew like the Star Wars 10th anniversary poster, which he both signed and numbered. None of the editions of this poster that I have seen advertised claimed to have been signed by Drew, so I do not think that he numbered them. He might have signed some, but I have never seen one.
Hellboy I is a bit murkier. Mine is not as thick as Hellboy II but slightly thicker than a conventional one sheet, single-sided and non-glossy. My copy was bought about one year after the poster's initial release and I have never seen this version advertised as signed and/or numbered. I have searched the internet for any reference to the existence of signed/numbered versions of this poster and have come up empty handed.
It might be possible that Mezco had some signed, but I would rather doubt it.
I hope this helps. If I can pull these posters for pics soon, I will do so and post.