A great pic of Karloff posing with a full head life casting of himself, in one of the studio makeup departments, that has been added to, to create a Frankenstein headpiece, that would have been molded out of latex. This is how many latex appliances were made, by first sculpting them, in clay, on a life mask of the actor, so that the final latex piece was a custom fit.
Looking at Karloff and his age, maybe this was a shot taken when he appeared one last time as The Monster, in an episode of the 1960s TV series, "Route 66," or maybe it was nothing more than a publicity shot taken, at some other time.